Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. Symptoms depend on the type and are often variable. They may include diarrhea, weight loss, feeling tired, enlargement of the tongue, bleeding, numbness, feeling faint with standing, swelling of the legs, or enlargement of the spleen.There are about 30 different types of amyloidosis, each due to a specific protein misfolding. Some are genetic while others are acquired. They are grouped into ...

amyloidosis

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Understanding-Alzheimer's-Disease

Understanding Alzheimer's Disease

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Alzheimer's Disease is a progressive neurological disorder that affects millions of people worldwide. It is the most common cause of dementia, leading to memory loss, cognitive decline, and behavioral changes. While the exact cause of Alzheimer's is still not fully understood, it is believed to be a combination of genetic, environmental, and lifestyle factors. Key risk factors include aging, a family history of Alzheimer's, and certain chronic health conditions like diabetes and heart disease.

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The Golden Spice and Alzheimer's Disease:

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Turmeric, a staple in traditional Indian cuisine, contains an active compound called curcumin. This powerful antioxidant and anti-inflammatory agent has been the focus of numerous scientific studies that aim to understand its potential benefits in preventing and treating Alzheimer's Disease.

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In one such study, researchers found that curcumin could inhibit the formation of amyloid-beta plaques, which are considered a hallmark of Alzheimer's Disease. These plaques build up in the brain, disrupting the communication between nerve cells and leading to cell death. Curcumin's potential to prevent plaque formation suggests a promising role in the fight against Alzheimer's Disease.<a href="https://www.bioseek.eu/us/eng/research/search?q=The%20effect%20of%20curcumin%20(turmeric)%20on%20Alzheimer%27s%20disease%3A%20An%20overview" target="_blank" data-ref="Publications about The effect of curcumin (turmeric) on Alzheimer's disease: An overview" rel="noopener">[ref. 1]</a>&nbsp;

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Another study showed that curcumin could help reduce inflammation in the brain, which is a contributing factor to the development of Alzheimer's. By lowering inflammation, curcumin may protect brain cells from damage and improve overall cognitive function.

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Turmeric-Recipes-for-Better-Brain-Health:

Turmeric Recipes for Better Brain Health:

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Incorporating turmeric into your diet can be both delicious and beneficial for your brain health. Here are some easy-to-make recipes featuring turmeric:

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1. Golden milk

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Heat up a cup of your favorite milk (dairy or plant-based), then stir in 1/2 teaspoon of turmeric powder, a pinch of black pepper, and a drizzle of honey. Enjoy this comforting beverage daily for a brain-boosting treat.

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2. Turmeric smoothie

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&nbsp;Blend together a banana, a handful of spinach, 1/2 teaspoon of turmeric powder, a pinch of black pepper, and a cup of your preferred milk. This vibrant smoothie is an excellent way to kickstart your day.

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3. Roasted vegetables with turmeric

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Toss your favorite vegetables (like cauliflower, carrots, and sweet potatoes) in a mixture of olive oil, turmeric, black pepper, and salt. Roast in the oven at 400&deg;F (200&deg;C) for 25-30 minutes until tender and golden. Enjoy these flavorful veggies as a healthy side dish.

A-Word-of-Caution

A Word of Caution

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While turmeric is generally safe for most people, it's important to remember that some individuals may be allergic to the spice. If you're considering adding turmeric to your diet, it's always a good idea to consult your healthcare provider, especially if you're taking medications or have existing health conditions.

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Questions-and-Answers

Questions and Answers

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Q: Can I use fresh turmeric instead of turmeric powder in the recipes?

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A: Absolutely! Fresh turmeric can be used as a substitute for turmeric powder. Just remember to peel the skin and finely grate it before adding it to your dishes. A general rule of thumb is to use 1 inch of fresh turmeric for every 1/2 teaspoon of turmeric powder.

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Q:How much turmeric should I consume daily for optimal benefits?

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A: There isn't a one-size-fits-all answer to this question, as individual needs may vary. However, a common recommendation is to consume 500-1,000 milligrams of curcumin per day, which equates to approximately 1-3 grams of turmeric powder. It's always best to consult with your healthcare provider for personalized advice.

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Q: Can I take turmeric supplements instead of incorporating it into my diet?

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A: Yes, turmeric supplements are available, and they can be a convenient way to ensure you're getting an adequate amount of curcumin. However, it's important to choose high-quality supplements from reputable manufacturers and follow the recommended dosage instructions. Consult your healthcare provider before starting any supplement regimen.

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Q:Is there any interaction between turmeric and medications?

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A: Turmeric can interact with certain medications, such as blood thinners, diabetes medications, and blood pressure medications. If you're taking any of these medications or have concerns about potential interactions, it's essential to consult with your healthcare provider before adding turmeric to your diet or taking supplements.

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Q: Why is black pepper often recommended alongside turmeric?

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A:Black pepper contains a compound called piperine, which significantly enhances the absorption of curcumin in the body. By combining turmeric with a pinch of black pepper, you can maximize the bioavailability and potential benefits of curcumin.

Turmeric, with its powerful active compound curcumin, has shown promising benefits in preventing and treating Alzheimer's Disease. Its ability to reduce inflammation and prevent the formation of amyloid-beta plaques may help protect brain cells and improve cognitive function. By incorporating turmeric into your diet with delicious and easy-to-make recipes, you can harness the potential benefits of this golden spice and support better brain health. As always, consult your healthcare provider before making significant changes to your diet, especially if you have existing health conditions or allergies. So why not give turmeric a try? Your taste buds and your brain will thank you!

The Amazing Benefits of Turmeric for Alzheimer's Disease

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What-are-Lion's-Mane-mushrooms-(Hericium-erinaceus)?

What are Lion's Mane mushrooms (Hericium erinaceus)?

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The lion's mane mushroom is first of all an edible mushroom, otherwise we would not write about it in such a context. And despite its fearsome name in our native language, Hericium erinaceus has irrefutable nicknames in other countries around the world. In Japan, it is known as Yamabushitake or "mushroom mountain monk". This is because the Buddhist monks of Yamabushi wear "suzukake" or a garment with long strands of hair or fur, Which resembles the mushroom. In China, it's Ho Tou Gu, the "monkey-headed mushroom." 1

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The shaggy appearance of the lion's mane also won him titles such as:

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<ul><li style="font-weight: 400;" aria-level="1">Mushroom bearded tooth</li><li style="font-weight: 400;" aria-level="1">Mushroom bearded hedgehog</li><li style="font-weight: 400;" aria-level="1">Satir's beard</li><li style="font-weight: 400;" aria-level="1">Mushroom pompom and other even more attractive.</li></ul>All of these names point to the unique orb shape characteristic of lion's mane mushrooms, making them easy to recognize in the wild, at farmers' markets, or on the rare occasions when found elsewhere.

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Like the reishi mushroom, lion's mane has been used for medicinal purposes for thousands of years (2000 BC, to be exact). In both Chinese and Japanese medicine, lion's mane "has traditionally been used to strengthen the spleen, nourish the intestines, and also as an anticancer drug."

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But what really makes lion's mane stand out from other mushrooms (aside from the fact that it looks like a lion's lush mane and tastes like crab or lobster), it's a natural nootropic. This means that it can naturally improve cognitive function. 2

How-the-Lion's-Mane-mushroom-works---active-ingredients

How the Lion's Mane mushroom works - active ingredients 

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Lion's mane contains various functional compounds, but two are the main substances that stand out:

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<ul><li style="font-weight: 400;" aria-level="1">Aromatic Hericenones</li><li style="font-weight: 400;" aria-level="1">Dieterpenoid erinacins</li></ul>No other food contains this powerful combination, which makes lion's mane exceptional.

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The chemical structures of these compounds are somewhat complex. Aromatics consist of loops bonded by covalent bonds (shared electrons). This adds a measure of stability known as aromaticity, hence the name.

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Diterpenes - naturally produced from plants, animals and fungi - have four isoprene units. Isoprene consists of two or more hydrocarbon units with a specific arrangement of carbon atoms.

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Neerinacin diterpenoids are found in other medicinal mushrooms and exhibit both antimicrobial and anti-inflammatory activity. But erinacins can do something unusual that non-erinacins cannot: cross the blood-brain barrier.&nbsp; (Hericenons may share this ability; but further study is needed for confirmation.) This hidden superpower is what gives the lion's mane mushroom its beneficial effect on the brain.

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The fruiting bodies of lion's mane contain two compounds that are called erinacin A and B. Both erinacins have been shown to promote nerve growth factor (NGF) synthesis, which has potential applications in dealing with multiple neurological conditions and disabilities. 3

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To date, more than 70 compounds have been identified in Hericium erinaceus. It's possible that this new data could help unravel some of the mysteries behind the lion's mane's incredible potential. 4

General-benefits-of-using-lion's-mane

General benefits of using lion's mane 

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Traditionally used to combat digestive disorders and stomach problems, the lion's mane mushroom has also been recognized as a restorative for overall health to support immunity and cognitive function.

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It is believed that the healing, regenerative nature of lion's mane helps to maintain the optimal condition of:&nbsp;

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<ul><li style="font-weight: 400;" aria-level="1">Liver</li><li style="font-weight: 400;" aria-level="1">Spleen</li><li style="font-weight: 400;" aria-level="1">Heart</li><li style="font-weight: 400;" aria-level="1">Lungs</li><li style="font-weight: 400;" aria-level="1">Kidneys</li></ul>Any "deficiency" in the body — thought to manifest externally with symptoms such as insomnia, weakness, and loss of strength — can be addressed with the help of Hericium erinaceus.

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Of course, lion's mane also has a long tradition of use for brain health. Some cultures recognize the fungus as an aid to memory, concentration, and overall mental function; Others point to the lion's mane mushroom to support nerve growth and repair, as well as for more clarity and focus.

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Seven-scientifically-based-benefits-of-lion's-mane-mushrooms

Seven scientifically based benefits of lion's mane mushrooms 

Protection-against-dementia-and-Alzheimer's-disease

Protection against dementia and Alzheimer's disease 

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One of the most impressive benefits of lion's mane mushrooms is that they can protect against dementia and Alzheimer's disease. Studies have shown that lion's mane can improve cognitive function and memory in people with mild to moderate forms of these diseases. Alzheimer's disease is the most common form of dementia, affecting at least 50 million people.&nbsp; Dementia is a general term used to describe the deterioration of mental functions that occurs with age. Symptoms may include memory loss, difficulty reasoning and problem solving, confusion, and changes in mood or behavior.

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Lion's mane contains compounds known as hericistins and erinacins, which have been shown to promote nerve growth and protect neurons from damage.

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The unique ability of erinacins to cross the blood-brain barrier and promote regenerative activity in the brain is the most important advantage of the lion's mane mushroom. Here it is important to explain more about the so-called. nerve growth factor (NGF).

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Nerve growth factor functions exactly as the name suggests: it regulates the growth and reproduction of nerve cells, supports cellular health, and prevents cell death. NGF is part of a family of molecules known as neurotrophic factors that support both mature and developing neurons.

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Neurotrophic factors allow the brain to heal and repair itself after an injury and maintain what's known as "brain neuroplasticity" throughout life. In other words, your brain never stops responding to information, thought patterns, and external stimuli, and NGF helps strengthen or even create important neural pathways in the brain.

Studies-in-people-with-dementia-for-the-use-of-lion's-mane

Studies in people with dementia for the use of lion's mane  

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Problems with cognition can arise when the brain fails to cope with the growth and formation of new connections as we age. The resulting cognitive decline can manifest as varying degrees of memory loss or dementia. Several studies have shown the potential of lion's mane for dementia prevention and cognitive support.

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In one of them, a group of 30 adults with "mild cognitive impairment" were divided into two groups and given either lion's mane or placebo. Those who took lion's mane supplements performed better on cognitive tests at weeks 8, 12 and 16 of the study. 5

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In studies on PC12 cells — used to study brain health and function — lion's mane appeared to prevent damage and reduce the occurrence of cell death.

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Even in healthy subjects, mushroom supplementation can improve the ability to recognize and recall previously learned information ("recognition memory") by exercising activity similar to brain-derived neurotrophic factor (BDNF). BDNF supports the plasticity of neurons, making learning, memorization and cognitive processes easier to run. 6

Studies-in-people-with-Alzheimer's-for-the-use-of-lion's-mane

Studies in people with Alzheimer's for the use of lion's mane 

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Currently, no human studies have been conducted to investigate the effects of Hericium erinaceus on Alzheimer's patients. In studies on mice, however, mushroom extracts were able to reduce symptoms of memory loss and prevent the accumulation of beta-amyloid (β-amyloid) plaques. Since the accumulation of β-amyloid plaques is a key factor in the development of Alzheimer's disease, this activity can have significant implications for the prevention or even treatment of the disease.&nbsp;

Relieving-symptoms-of-anxiety-and-depression

Relieving symptoms of anxiety and depression 

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Lion's mane isn't just a strength for memory — it can also help your mood. Hericium erinaceus extracts appear to regenerate cells in the hippocampus, the area of the brain responsible for emotional response and memories. In a mouse model, the fungus shows the potential to support neurogenesis, the process of growing new nerve cells.

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The practical daily benefit of all this can be seen in studies related to anxiety and depression. A four-week study involving a group of 30 postmenopausal women found that cookies made with lion's mane were better than placebo cookies at reducing anxiety and irritability. 7

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Lion's mane extracts have been shown to block the signaling power of nuclear factor-kappa beta (NF-kB), a protein complex responsible for promoting inflammation by inducing synthesis of pro-inflammatory compounds. The fungus may also reduce elevated levels of two pro-inflammatory cytokines, known as IL-6 and TNF-alpha.

Recovery-Benefits-from-Nervous-System-Injuries

Recovery Benefits from Nervous System Injuries 

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The brain, spinal cord and other nerves that travel around the body are part of the nervous system. These elements collaborate to transmit and exchange messages that control almost all bodily functions. Injuries to the brain or spinal cord can be fatal. They often lead to paralysis or loss of mental abilities, and the recovery time is long.

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However, lion's mane mushroom extract has been shown in studies to promote the growth and repair of nerve cells, which may help in recovering from this type of injury. Lion's mane extract may also help reduce the severity of brain damage after a stroke.

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In one study, high doses of lion's mane mushroom extract given to rats immediately after a stroke helped reduce inflammation and reduce the size of stroke-related brain damage by 44%.

Improved-protection-against-ulcers-in-the-digestive-tract

Improved protection against ulcers in the digestive tract 

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Stomach ulcers are usually a consequence of two main factors: overgrowth of H. pylori and damage to the gastric mucosa caused by long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).

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Lion mane extract, when taken correctly, has been found to protect against the development of stomach ulcers by inhibiting the growth of H. pylori and protecting the gastric mucosa from damage. This was attributed to a polysaccharide fraction isolated from a mycelial culture of the medical fungus.&nbsp;

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Anti-inflammatory-action-and-reduction-of-oxidative-stress

Anti-inflammatory action and reduction of oxidative stress 

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The lion's mane mushroom contains powerful anti-inflammatory and antioxidant chemicals that can help manage inflammatory conditions. In fact, one study comparing the antioxidant abilities of 14 different species of mushrooms found that lion's mane had the fourth highest antioxidant activity.&nbsp;

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In rats, lion's mane extract reduces inflammation and indicators of oxidative stress, suggesting it may be particularly useful in the treatment of inflammatory bowel disease, liver damage and stroke. It is necessary to investigate whether it has the same effect in humans in larger studies.&nbsp;

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Anti-cancer action of the mushroom Lion's mane 

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When lion's mane extract combines with human cancer cells in a test tube, it causes cancer cells to die at a faster rate. This is seen in many types of cancer cells, including tumors of the liver, colon, stomach and blood. 8

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In another study, we find that diterpene shows good cytotoxic activity against two human cancer cell lines - K562, LANCAP and HEP2. 9

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Antioxidant power and skin protection with Lion's Mane mushrooms 

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When the body is stressed or exposed to chemicals — whether in the environment or food — compounds known as free radicals are formed. Antioxidants like those found in lion's mane have the ability to "donate" electrons to free radicals, which neutralizes compounds while protecting healthy cells. The result is less inflammation and a lower risk of cell damage.

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According to research, lion's mane may have specific benefits associated with this anti-inflammatory activity, including:

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<ul><li style="font-weight: 400;" aria-level="1">Reduce skin aging by increasing levels of skin antioxidants and collagen proteins</li><li style="font-weight: 400;" aria-level="1">Reduce prooxidant reactive oxygen species and increase antioxidant levels in the brain</li><li style="font-weight: 400;" aria-level="1">An increase in antioxidants and a decrease in lipid peroxidation in diabetic rat models, suggesting potential applications for the management of diabetic neuropathy.</li></ul>

If you are looking for a way to improve your brain function, memory and immunity, you can do so with the help of the lion's mane mushroom. This small mushroom is rich in nutrients that can help improve nerve function, antioxidant protection, and relieve symptoms of anxiety and depression. Their potency has also been shown in conditions such as Alzheimer's, as well as in several types of cancer.&nbsp; Lion's Mane mushrooms have powerful anti-inflammatory, antioxidant and immunostimulating properties, as well as the ability to reduce the incidence of heart disease, ulcers and diabetes in animals, and in some areas in humans. More testing is needed on the applications of this fungus in humans to reveal its potential mechanisms.

The mysterious properties of Lion's Mane mushroom (Hericium erinaceus)

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The mysterious properties of Lion's Mane mushroom (Hericium erinac)

Бетина Цветкова

The-most-important-thing-about-olive-oil-(olive-oil)

The most important thing about olive oil (olive oil) 

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Olive oil is a type of vegetable oil extracted from the flesh of the ripe fruit of the olive tree, Olea europaea. The color of olive oil varies from transparent yellow to golden; Some varieties obtained from unripe fruits have a greenish tint. Oils with different characteristics and qualities are produced by almost every country that grows olives, with variations depending on the area and maturity of the fruit. Among the best types of olive oil are those produced in Italy, Greece and other countries.&nbsp;

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Pure olive oil is mainly used for culinary purposes and for preserving foods, especially canned fish. It is also used in the textile industry, in the production of toilet preparations and cosmetics, in the pharmaceutical industry for medical purposes, in the production of high-quality Castilian soap and as a lubricant. &nbsp;<a href="https://www.frontiersin.org/articles/10.3389/fphar.2021.723040/full" target="_blank" data-ref="Olive Oil: Nutritional Applications, Beneficial Health Aspects and its Prospective Application in Poultry Production" rel="noopener">[ref. 1]</a>&nbsp;

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Ripe olive fruits with the removed pit contain 20 to 30 percent oil depending on the climate and care of cultivation. Olive oils obtained by the first mechanical pressing without further processing are called untreated, and their quality depends on the condition of the fruit. Only oils of the best fruits are edible without further processing. They are rarely exported without processing, but can be used as a basis for export oil or consumed locally.&nbsp;

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To prevent the formation of free fatty acids, the best quality edible oil should be removed from the pulp as soon as possible. After the initial pressing, the residual slurry is repressed with hot water and from this second pressing an oil with a higher acid content is obtained. This oil, along with lower-quality virgin oils, makes up the oil, called lampante, due to its use as a fuel in lamps. This species is further refined to remove acid, color, and odor, and is sold as refined olive oil.

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Olive oil is a central component of the so-called Mediterranean diet, which is considered particularly beneficial for cardiovascular health. <a href="https://pubmed.ncbi.nlm.nih.gov/31243760/" target="_blank" data-ref="Mediterranean diet and health status: Active ingredients and pharmacological mechanisms - PubMed" rel="noopener">[ref. 2]</a>&nbsp; Olive oil is rich in antioxidants, including polyphenols, and in healthy monounsaturated fatty acids.&nbsp; Studies of olive oil have shown that consumption of oil, especially in the form of extra virgin olive oil, is associated with a reduced risk of cardiovascular disease and type 2 diabetes mellitus, and with a reduction in brain inflammation and amyloid-beta plaque formation. These plaques are characteristic of Alzheimer's disease.&nbsp;

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Animal and human studies have also shown that a diet rich in olive oil may help protect against memory loss and dementia-related damage. These beneficial and health-promoting effects of olive oil are due to the content of polyphenols, which have powerful antimutagenic, anti-inflammatory, antithrombotic and antiallergic effects. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/28973999/" target="_blank" data-ref="Effects of Olive Oil Phenolic Compounds on Inflammation in the Prevention and Treatment of Coronary Artery Disease - PubMed" rel="noopener">[ref. 3]</a>&nbsp;

Olive oil is widely recognized as one of the healthiest oils in the world. In fact, people tend to live longer and healthier lives in regions where olive oil is a major part of the diet. It is also a major component of the Mediterranean diet, along with other foods rich in healthy fats. Extra virgin olive oil (EVOO) is the highest quality olive oil available, extracted from the fruit of the olive without the use of heat or chemicals. There are four other types of olive oil, which are also used in cooking, cosmetics and other areas. The many benefits of olive oil and its wide application make it a preferred vegetable oil in many countries around the world.

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